Read Online Wheat Belly: Lose the Wheat, Lose the Weight and Find Your Path Back to Health by William Davis - Free Book Online
Authors: William Davis
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substantial proportion of children and adults with attention deficit/hyperactivity disorder (ADHD) may also respond to elimination of wheat. However, responses are often muddied due to sensitivities to other components of diet, such as sugars, artificial sweeteners, additives, and dairy. 10
It is unlikely that wheat exposure was the initial
cause
of autism or ADHD but, as with schizophrenia, wheat appears to be associated with worsening of the symptoms characteristic of the conditions.
Though the laboratory rat treatment of the unsuspecting schizophrenic patients in the Philadelphia VA Hospital may send chills down our spines from the comfort of our fully informed and consenting twenty-first century, it is nevertheless a graphic illustration of wheat’s effect on mental function. But why in the world are schizophrenia, autism, and ADHD exacerbated by wheat? What is in this grain that worsens psychosis and other abnormal behaviors?
Investigators at the National Institutes of Health (NIH) set out to find some answers.
EXORPHINS: THE WHEAT-MIND CONNECTION
Dr. Christine Zioudrou and her colleagues at the NIH subjected gluten, the main protein of wheat, to a simulated digestive process to mimic what happens after we eat bread or other wheat-containing products. 11 Exposed to pepsin (a stomach enzyme) and hydrochloric acid (stomach acid), gluten is degraded to a mix of polypeptides. The dominant polypeptides were then isolated and administered to laboratory rats. These polypeptides were discovered to have the peculiar ability to penetrate the blood-brain barrier that separates the bloodstream from the brain. This barrier is there for a reason: The brain is highly sensitive to the wide variety of substances that gain entry to the blood, some of which can provokeundesirable effects should they cross into your amygdala, hippocampus, cerebral cortex, or other brain structure. Once having gained entry into the brain, wheat polypeptides bind to the brain’s morphine receptor, the very same receptor to which opiate drugs bind.
Zioudrou and her colleagues dubbed these polypeptides “exorphins,” short for exogenous morphine-like compounds, distinguishing them from endorphins, the endogenous (internally sourced) morphine-like compounds that occur, for instance, during a “runner’s high.” They named the dominant polypeptide that crossed the blood-brain barrier “gluteomorphin,” or morphinelike compound from gluten (though the name sounds to me more like a morphine shot in the butt). The investigators speculated that exorphins might be the active factors derived from wheat that account for the deterioration of schizophrenic symptoms seen in the Philadelphia VA Hospital and elsewhere.
Even more telling, the brain effect of gluten-derived polypeptides is blocked by administration of the drug naloxone.
Let’s pretend you’re an inner-city heroin addict. You get knifed during a drug deal gone sour and get carted to the nearest trauma emergency room. Because you’re high on heroin, you kick and scream at the ER staff trying to help you. So these nice people strap you down and inject you with a drug called naloxone, and you are instantly
not
high. Through the magic of chemistry, naloxone immediately reverses the action of heroin or any other opiate drug such as morphine or oxycodone.
In lab animals, administration of naloxone blocks the binding of wheat exorphins to the morphine receptor of brain cells. Yes, opiate-blocking naloxone prevents the binding of wheat-derived exorphins to the brain. The very same drug that turns off the heroin in a drug-abusing addict also blocks the effects of wheat exorphins.
In a World Health Organization study of thirty-two schizophrenic people with active auditory hallucinations, naloxone wasshown to reduce hallucinations. 12 Unfortunately, the next logical step—administering naloxone to schizophrenics eating a “normal” wheat-containing diet compared to schizophrenics administered
It is unlikely that wheat exposure was the initial
cause
of autism or ADHD but, as with schizophrenia, wheat appears to be associated with worsening of the symptoms characteristic of the conditions.
Though the laboratory rat treatment of the unsuspecting schizophrenic patients in the Philadelphia VA Hospital may send chills down our spines from the comfort of our fully informed and consenting twenty-first century, it is nevertheless a graphic illustration of wheat’s effect on mental function. But why in the world are schizophrenia, autism, and ADHD exacerbated by wheat? What is in this grain that worsens psychosis and other abnormal behaviors?
Investigators at the National Institutes of Health (NIH) set out to find some answers.
EXORPHINS: THE WHEAT-MIND CONNECTION
Dr. Christine Zioudrou and her colleagues at the NIH subjected gluten, the main protein of wheat, to a simulated digestive process to mimic what happens after we eat bread or other wheat-containing products. 11 Exposed to pepsin (a stomach enzyme) and hydrochloric acid (stomach acid), gluten is degraded to a mix of polypeptides. The dominant polypeptides were then isolated and administered to laboratory rats. These polypeptides were discovered to have the peculiar ability to penetrate the blood-brain barrier that separates the bloodstream from the brain. This barrier is there for a reason: The brain is highly sensitive to the wide variety of substances that gain entry to the blood, some of which can provokeundesirable effects should they cross into your amygdala, hippocampus, cerebral cortex, or other brain structure. Once having gained entry into the brain, wheat polypeptides bind to the brain’s morphine receptor, the very same receptor to which opiate drugs bind.
Zioudrou and her colleagues dubbed these polypeptides “exorphins,” short for exogenous morphine-like compounds, distinguishing them from endorphins, the endogenous (internally sourced) morphine-like compounds that occur, for instance, during a “runner’s high.” They named the dominant polypeptide that crossed the blood-brain barrier “gluteomorphin,” or morphinelike compound from gluten (though the name sounds to me more like a morphine shot in the butt). The investigators speculated that exorphins might be the active factors derived from wheat that account for the deterioration of schizophrenic symptoms seen in the Philadelphia VA Hospital and elsewhere.
Even more telling, the brain effect of gluten-derived polypeptides is blocked by administration of the drug naloxone.
Let’s pretend you’re an inner-city heroin addict. You get knifed during a drug deal gone sour and get carted to the nearest trauma emergency room. Because you’re high on heroin, you kick and scream at the ER staff trying to help you. So these nice people strap you down and inject you with a drug called naloxone, and you are instantly
not
high. Through the magic of chemistry, naloxone immediately reverses the action of heroin or any other opiate drug such as morphine or oxycodone.
In lab animals, administration of naloxone blocks the binding of wheat exorphins to the morphine receptor of brain cells. Yes, opiate-blocking naloxone prevents the binding of wheat-derived exorphins to the brain. The very same drug that turns off the heroin in a drug-abusing addict also blocks the effects of wheat exorphins.
In a World Health Organization study of thirty-two schizophrenic people with active auditory hallucinations, naloxone wasshown to reduce hallucinations. 12 Unfortunately, the next logical step—administering naloxone to schizophrenics eating a “normal” wheat-containing diet compared to schizophrenics administered
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