asked.
“A long time ago, with a much coarser suppressant.” If she hadn’t heard of that work it was because nothing much had come of it. Carlo didn’t want to waste time repeating other people’s experiments, but the new preparation Tosco had discovered blocked signaling in a smaller volume of tissue, and also seemed to have fewer side effects. “I’m not expecting to find some magic spot where we can interrupt transmission and see the number of offspring halved,” he said. “But to get anywhere, we’re going to need the best map we can make of the pathways that influence fission. Even these tiny doses will probably interfere with a dozen individual pathways, but that will still be a big improvement on the last map.”
Amanda said, “I’ve had some success with microsurgery, for identifying phalangeal control pathways in lizards.”
Carlo was intrigued. “So you cut into the leg under a microscope… and managed to paralyze a particular toe ?”
“Almost,” she replied. “I have to infer things from incremental damage—I can’t actually sever the pathway for any given toe without severing other things as well. And of course the lizards either re-route the signals within a chime or two, or resorb the whole limb and reconstruct it.”
The female vole had already been limbless in her mating posture, but now her body was deforming further into an almost featureless ellipsoid. Carlo could just make out a shallow longitudinal trench that marked the beginning of the primary partition. Whatever change the injection had wrought, it hadn’t suppressed the start of fission itself.
“So you know how to paralyze a lizard,” Carlo said, “but have you ever thought of doing the reverse?”
Amanda buzzed softly. “The old yellow flash muscle twitch? I know it impresses students, but I’m not sure that there’s much to be learned that way.”
“I was thinking of something subtler than a twitch,” he said. “Imagine severing the pathways from the brain… but then introducing motor signals of your own.”
Amanda was skeptical. “Even if we could manage the mechanics of an intervention like that, we’d have no way of knowing the proper time sequences for the signals. Believe me, I’ve stared down a microscope at enough flickering lizard tissue to know that I’m never going to be able to transcribe what’s happening.”
“I have some ideas about that,” Carlo confided. Faint lines could now be seen neatly dividing each half of the vole blastula, displaced to the usual degree above the midline to guarantee an extra quota of flesh to the daughters. The father-to-be screeched triumphantly, as if he knew that his captors had been thwarted. But any celebration was premature; in the old studies a similarly placed dose of suppressant had led to stillborn males.
“What ideas?” Amanda pressed him.
“Run a long strip of light-sensitive paper past a probe into the tissue,” Carlo replied. “Turn the variation of light over time into a variation over space. You could have the whole history of a motor sequence spread out in front of you, to read at your leisure.”
Amanda thought it over. “I suppose that might work.” She shifted her grip on one of the ropes they shared, sending a brief shudder through Carlo’s body.
“You could copy the pattern,” he said. “Maybe modify it too. Then send it back into the body using a strip of paper of variable transparency, moving in front of a light source. But the beauty of it is, you could send it back to a completely different site, if you wanted to. Maybe even send it into a completely different animal.”
Amanda buzzed softly, not quite mocking him but amused at his audacity. “So that’s the plan? Record the way a biparous animal initiates fission, then feed those signals into a quadraparous species in place of their own version of the sequence?”
“I don’t know,” Carlo said. “Maybe that’s naïve. The difference might not come down to
“A long time ago, with a much coarser suppressant.” If she hadn’t heard of that work it was because nothing much had come of it. Carlo didn’t want to waste time repeating other people’s experiments, but the new preparation Tosco had discovered blocked signaling in a smaller volume of tissue, and also seemed to have fewer side effects. “I’m not expecting to find some magic spot where we can interrupt transmission and see the number of offspring halved,” he said. “But to get anywhere, we’re going to need the best map we can make of the pathways that influence fission. Even these tiny doses will probably interfere with a dozen individual pathways, but that will still be a big improvement on the last map.”
Amanda said, “I’ve had some success with microsurgery, for identifying phalangeal control pathways in lizards.”
Carlo was intrigued. “So you cut into the leg under a microscope… and managed to paralyze a particular toe ?”
“Almost,” she replied. “I have to infer things from incremental damage—I can’t actually sever the pathway for any given toe without severing other things as well. And of course the lizards either re-route the signals within a chime or two, or resorb the whole limb and reconstruct it.”
The female vole had already been limbless in her mating posture, but now her body was deforming further into an almost featureless ellipsoid. Carlo could just make out a shallow longitudinal trench that marked the beginning of the primary partition. Whatever change the injection had wrought, it hadn’t suppressed the start of fission itself.
“So you know how to paralyze a lizard,” Carlo said, “but have you ever thought of doing the reverse?”
Amanda buzzed softly. “The old yellow flash muscle twitch? I know it impresses students, but I’m not sure that there’s much to be learned that way.”
“I was thinking of something subtler than a twitch,” he said. “Imagine severing the pathways from the brain… but then introducing motor signals of your own.”
Amanda was skeptical. “Even if we could manage the mechanics of an intervention like that, we’d have no way of knowing the proper time sequences for the signals. Believe me, I’ve stared down a microscope at enough flickering lizard tissue to know that I’m never going to be able to transcribe what’s happening.”
“I have some ideas about that,” Carlo confided. Faint lines could now be seen neatly dividing each half of the vole blastula, displaced to the usual degree above the midline to guarantee an extra quota of flesh to the daughters. The father-to-be screeched triumphantly, as if he knew that his captors had been thwarted. But any celebration was premature; in the old studies a similarly placed dose of suppressant had led to stillborn males.
“What ideas?” Amanda pressed him.
“Run a long strip of light-sensitive paper past a probe into the tissue,” Carlo replied. “Turn the variation of light over time into a variation over space. You could have the whole history of a motor sequence spread out in front of you, to read at your leisure.”
Amanda thought it over. “I suppose that might work.” She shifted her grip on one of the ropes they shared, sending a brief shudder through Carlo’s body.
“You could copy the pattern,” he said. “Maybe modify it too. Then send it back into the body using a strip of paper of variable transparency, moving in front of a light source. But the beauty of it is, you could send it back to a completely different site, if you wanted to. Maybe even send it into a completely different animal.”
Amanda buzzed softly, not quite mocking him but amused at his audacity. “So that’s the plan? Record the way a biparous animal initiates fission, then feed those signals into a quadraparous species in place of their own version of the sequence?”
“I don’t know,” Carlo said. “Maybe that’s naïve. The difference might not come down to
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